Publications

2023

High-throughput anaerobic screening for identifying compounds acting against gut bacteria in monocultures or communities.

Patrick Müller *Jacobo de la Cuesta-Zuluaga*Michael KuhnMaral Baghai ArassiTim TreisSonja BlascheMichael ZimmermannPeer BorkKiran Raosaheb PatilAthanasios TypasSarela Garcia-Santamarina#, Lisa Maier #
 

Non-antibiotic drugs break colonization resistance against pathogenic Gammaproteobacteria.

Anne Grießhammer*, Jacobo de la Cuesta-Zuluaga*, Taiyeb Zahir*Patrick MüllerCordula Gekeler, Hsuan Chang, Katharina Schmitt, Chiara PlankerErwin Bohn, Taylor H. Nguyen, Kerwyn Casey Huang, Lisa Maier

bioRxiv,

Pioneering microbiome engineering.

Lisa Maier

Nature Reviews Microbiology, 21, page 630 (2023)

Consistency across multi-omics layers in a drug-perturbed gut microbial community.

Sander Wuyts, Renato Alves, Maria Zimmermann-Kogadeeva, Suguru Nishijima, Sonja Blasche, Marja Driessen, Philipp E Geyer, Rajna Hercog, Ece Kartal, Lisa Maier, Johannes B Müllerm, Sarela Garcia Santamarina, Thomas Sebastian B Schmidt, Daniel C Sevin, Anja Telzerow, Peter V Treit, Tobias Wenzel, Athanasios Typas, Kiran R Patil, Matthias Mann, Michael Kuhn, Peer Bork

Molecular Systems Biology (2023)19:e11525

Confounder or Confederate? The Interactions Between Drugs and the Gut Microbiome in Psychiatric and Neurological Diseases.

Lena Michaelis, Lara Berg, Lisa Maier (2023)

Biological Psychiatry, available online 17 June 2023

Gut bacteria thwart the blood sugar-lowering effect of acarbose.

Melanie M Brauny, Lisa Maier (2023)

Nature Metabolism
 

 A MALDI-TOF MS library for rapid identification of human commensal gut bacteria from the class Clostridia.

Paul Tetteh Asare, Chi-Hsien Lee, Vera Hürlimann, Youzheng Teo, Aline Cuénod, Nermin Akduman, Cordula Gekeler, Afrizal Afrizal, Myriam Corthesy, Claire Kohout, Vincent Thomas, Tomas de Wouters, Gilbert Greub, Thomas Clavel, Eric G Pamer, Adrian Egli, Lisa Maier, Pascale Vonaesch (2023)

Front Microbiol., 14: 1104707

The cyanobacterial “nutraceutical” phycocyanobilin inhibits cysteine protease legumain.

Isabel VL Wilkinson, Gabriel Castro‐Falcón, Maria C Roda‐Serrat, Trevor N Purdy, Jan Straetener, Melanie M Brauny, Lisa Maier, Heike Brötz‐Oesterhelt, Lars P Christensen, Stephan A Sieber, Chambers C Hughes (2023)

ChemBioChem, 5, e202200455

2022

Codiversification of gut microbiota with humans.

Suzuki, T. A., Fitzstevens, L., Schmidt, V.T.,  Enav‚ H., Huus, K. E., Mbong Ngwese, M., Grießhammer, A., Pfleiderer, A., Adegbite, B., R., Zinsou, J. F., Esen, M., Velavan, T., P., Adegnika, A. A., Huu Song, L., Spector, T. D., Muehlbauer, A. L., Marchi, N., Kang, H., Maier, L., Blekhman, R., Ségurel, L., Ko, G., Youngblut, N. D., Kremser, P., Ley, R. E.  (2022).

Science, 377, pages 1328-1332

2021

Unravelling the collateral damage of antibiotics on gut bacteria.

Maier, L.#*, Goemans, C. V.*, Wirbel, J., Kuhn, M., Eberl, C., Pruteanu, M., Müller, P., Garcia-Santamarina, S., Cacace, E., Zhang, B., Gekeler, C., Banerjee, T., Anderson, E. E., Milanese, A., Löber, U., Forslund, S. K., Patil, K. R., Zimmermann, M., Stecher, B., … Typas, A.# (2021).

Nature, 599, pages 120-124

Bioaccumulation of therapeutic drugs by human gut bacteria.

Klünemann, M., Andrejev, S., Blasche, S., Mateus, A., Phapale, P., Devendran, S., Vappiani, J., Simon, B., Scott, T. A., Kafkia, E., Konstantinidis, D., Zirngibl, K., Mastrorilli, E., Banzhaf, M., Mackmull, M.-T., Hövelmann, F., Nesme, L., Brochado, A. R., Maier, L., … Patil, K. R. (2021).

Nature, 597, 533-538

Towards a mechanistic understanding of reciprocal drug-microbiome interactions.

Zimmermann, M.#, Patil, K. R., Typas, A., & Maier, L.# (2021).

Molecular Systems Biology, 17(3), e10116.

2019

Escherichia coli limits Salmonella Typhimurium infections after diet shifts and fat-mediated microbiota perturbation in mice.

Wotzka, S. Y., Kreuzer, M., Maier, L., Arnoldini, M., Nguyen, B. D., Brachmann, A. O., Berthold, D. L., Zünd, M., Hausmann, A., Bakkeren, E., Hoces, D., Gül, E., Beutler, M., Dolowschiak, T., Zimmermann, M., Fuhrer, T., Moor, K., Sauer, U., Typas, A., … Hardt, W.-D. (2019).

Nature Microbiology, 4(12), 2164–2174.

Komplexe Wechselwirkungen zwischen Arzneimitteln und dem Mikrobiom.

Maier, L. (2019). 

BIOspektrum, 25(7), 707–710.

2018

Microbiota stability in healthy individuals after single-dose lactulose challenge—A randomized controlled study.

Wotzka, S. Y.*, Kreuzer, M.*, Maier, L.*, Zünd, M., Schlumberger, M., Nguyen, B., Fox, M., Pohl, D., Heinrich, H., Rogler, G., Biedermann, L., Scharl, M., Sunagawa, S., Hardt, W.-D., & Misselwitz, B. (2018).

PLOS ONE, 13(10), e0206214.

Extensive impact of non-antibiotic drugs on human gut bacteria.

Maier, L.*, Pruteanu, M.*, Kuhn, M.*, Zeller, G., Telzerow, A., Anderson, E. E., Brochado, A. R., Fernandez, K. C., Dose, H., Mori, H., Patil, K. R., Bork, P., & Typas, A. (2018).

Nature, 555(7698), 623–628.

2017

Systematically investigating the impact of medication on the gut microbiome.

Maier, L., & Typas, A. (2017).

Current Opinion in Microbiology, 39, 128–135.

Salt-responsive gut commensal modulates TH17 axis and disease.

Wilck, N., Matus, M. G., Kearney, S. M., Olesen, S. W., Forslund, K., Bartolomaeus, H., Haase, S., Mähler, A., Balogh, A., Markó, L., Vvedenskaya, O., Kleiner, F. H., Tsvetkov, D., Klug, L., Costea, P. I., Sunagawa, S., Maier, L., Rakova, N., Schatz, V., … Müller, D. N. (2017).

Nature, 551(7682), 585–589.

2015

Granulocytes Impose a Tight Bottleneck upon the Gut Luminal Pathogen Population during Salmonella Typhimurium Colitis.

Maier, L., Diard, M., Sellin, M. E., Chouffane, E.-S., Trautwein-Weidner, K., Periaswamy, B., Slack, E., Dolowschiak, T., Stecher, B., Loverdo, C., Regoes, R. R., & Hardt, W.-D. (2014).

PLoS Pathogens, 10(12), e1004557.

Salmonella Typhimurium Strain ATCC14028 Requires H2-Hydrogenases for Growth in the Gut, but Not at Systemic Sites.

Maier, L., Barthel, M., Stecher, B., Maier, R. J., Gunn, J. S., & Hardt, W.-D. (2014).

PLoS ONE, 9(10), e110187.

2013

“Blooming” in the gut: How dysbiosis might contribute to pathogen evolution.

Stecher, B., Maier, L., & Hardt, W.-D. (2013).

Nature Reviews. Microbiology, 11(4), 277–284.

Microbiota-Derived Hydrogen Fuels Salmonella Typhimurium Invasion of the Gut Ecosystem.

Maier, L., Vyas, R., Cordova, C. D., Lindsay, H., Schmidt, T. S. B., Brugiroux, S., Periaswamy, B., Bauer, R., Sturm, A., Schreiber, F., von Mering, C., Robinson, M. D., Stecher, B., & Hardt, W.-D. (2013).

Cell Host & Microbe, 14(6), 641–651.

Stabilization of cooperative virulence by the expression of an avirulent phenotype.

Diard, M., Garcia, V., Maier, L., Remus-Emsermann, M. N. P., Regoes, R. R., Ackermann, M., & Hardt, W.-D. (2013).

Nature, 494(7437), 353–356.

2012

Live attentuated S. Typhimurium vaccine with improved safety in immuno-compromised mice. 

Periaswamy, B., Maier, L., Vishwakarma, V., Slack, E., Kremer, M., Andrews-Polymenis, H. L., McClelland, M., Grant, A. J., Suar, M., & Hardt, W.-D. (2012).

PloS One, 7(9), e45433.

Peroral ciprofloxacin therapy impairs the generation of a protective immune response in a mouse model for Salmonella enterica serovar Typhimurium diarrhea, while parenteral ceftriaxone therapy does not.

Endt, K.*, Maier, L.*, Käppeli, R., Barthel, M., Misselwitz, B., Kremer, M., & Hardt, W.-D. (2012).

Antimicrobial Agents and Chemotherapy, 56(5), 2295–2304.

Gut inflammation can boost horizontal gene transfer between pathogenic and commensal Enterobacteriaceae.

Stecher, B., Denzler, R., Maier, L., Bernet, F., Sanders, M. J., Pickard, D. J., Barthel, M., Westendorf, A. M., Krogfelt, K. A., Walker, A. W., Ackermann, M., Dobrindt, U., Thomson, N. R., & Hardt, W.-D. (2012).

PNAS, 109(4), 1269–1274.

2010

Glycosylation of wall teichoic acid in Staphylococcus aureus by TarM.

Xia, G., Maier, L., Sanchez-Carballo, P., Li, M., Otto, M., Holst, O., & Peschel, A. (2010).

The Journal of Biological Chemistry, 285(18), 13405–13415.

————————————————————————————————————————

* equal contribution, # corresponding authors