2024

Parkinson’s drug starves gut microbes of iron.

Jan Homolak, Lara Berg, Lisa Maier

Nat Microbiol, Published online November 22, 2024, DOI: 10.1016/j.tim.2024.09.011

Balancing Act: Counteracting Adverse Drug Effects on the Microbiome.

Jacobo De la Cuesta-Zuluaga, Patrick Müller, Lisa Maier

Trends Microbiol. Published online October 11, 2024, DOI: 10.1016/j.tim.2024.09.011

Emergence of community behaviors in the gut microbiota upon drug treatment.

Garcia-Santamarina, S., Kuhn, M., Devendran, S., Maier, L., Driessen, M., Mateus, A., Mastrorilli, E., Brochado, A.R., Savitski, M.M., Patil, K.R., Zimmermann, M., Bork, P., Typas, A.

Cell (2024) 187, 1–12. https://doi.org/10.1016/j.cell.2024.08.037

Proton-pump inhibitors increase C. difficile infection risk by altering pH rather than by affecting the gut microbiome based on a bioreactor model

,, Johannes Sulzer,,,

bioRxiv, doi: https://doi.org/10.1101/2024.07.10.602898

Antimicrobial Evaluation of Two Polycyclic Polyprenylated Acylphloroglucinol Compounds: PPAP23 and PPAP53

Aparna Viswanathan Ammanath, Miki Matsuo, Huanhuan Wang, Frank Kraus , Anton Bleisch,Philipp Peslalz, Majd Mohammad, Meghshree Deshmukh, Anne Grießhammer,Moushumi Purkayastha, Andreas Vorbach, Boris Macek, Heike Brötz-Oesterhelt, Lisa Maier,Dorothee Kretschmer, Andreas Peschel, Tao Jin, Bernd Plietker and Friedrich Götz

J. Mol. Sci., (2024) 25, 8023. https://doi.org/10.3390/ijms25158023

Response, resistance, and recovery of gut bacteria to human-targeted drug exposure

Jacobo de la Cuesta-Zuluaga, Leonardo Boldt, Lisa Maier

Cell Host Microbe (2024) https://doi.org/10.1016/j.chom.2024.05.009

Integrating research on bacterial pathogens and commensals to fight infections—an ecological perspective

Lisa Maier, Christoph Stein-Thoeringer, Ruth E Ley, Heike Brötz-Oesterhelt, Hannes Link, Nadine Ziemert, Samuel Wagner, Andreas Peschel

The Lancet Microbe (2024) https://doi.org/10.1016/S2666-5247(24)00049-1

2023

High-throughput anaerobic screening for identifying compounds acting against gut bacteria in monocultures or communities.

Patrick Müller^*, Jacobo de la Cuesta-Zuluaga^*, Michael Kuhn, Maral Baghai Arassi, Tim Treis, Sonja Blasche, Michael Zimmermann, Peer Bork, Kiran Raosaheb Patil, Athanasios Typas, Sarela Garcia-Santamarina^#, Lisa Maier^#

Nat Protoc (2023). https://doi.org/10.1038/s41596-023-00926-4

Non-antibiotic drugs break colonization resistance against pathogenic Gammaproteobacteria.

Anne Grießhammer*, Jacobo de la Cuesta-Zuluaga*, Taiyeb Zahir*, Patrick Müller, Cordula Gekeler, Hsuan Chang, Katharina Schmitt, Chiara Planker, Erwin Bohn, Taylor H. Nguyen, Kerwyn Casey Huang, Lisa Maier

bioRxiv, doi: https://doi.org/10.1101/2023.11.06.564936

Pioneering microbiome engineering.

Lisa Maier

Nature Reviews Microbiology, 21, page 630 (2023)

Consistency across multi-omics layers in a drug-perturbed gut microbial community.

Sander Wuyts, Renato Alves, Maria Zimmermann-Kogadeeva, Suguru Nishijima, Sonja Blasche, Marja Driessen, Philipp E Geyer, Rajna Hercog, Ece Kartal, Lisa Maier, Johannes B Müllerm, Sarela Garcia Santamarina, Thomas Sebastian B Schmidt, Daniel C Sevin, Anja Telzerow, Peter V Treit, Tobias Wenzel, Athanasios Typas, Kiran R Patil, Matthias Mann, Michael Kuhn, Peer Bork

Molecular Systems Biology (2023)19:e11525

Confounder or Confederate? The Interactions Between Drugs and the Gut Microbiome in Psychiatric and Neurological Diseases.

Lena Michaelis, Lara Berg, Lisa Maier (2023)

Biological Psychiatry, available online 17 June 2023

Gut bacteria thwart the blood sugar-lowering effect of acarbose.

Melanie M Brauny, Lisa Maier (2023)

Nature Metabolism

A MALDI-TOF MS library for rapid identification of human commensal gut bacteria from the class Clostridia.

Paul Tetteh Asare, Chi-Hsien Lee, Vera Hürlimann, Youzheng Teo, Aline Cuénod, Nermin Akduman, Cordula Gekeler, Afrizal Afrizal, Myriam Corthesy, Claire Kohout, Vincent Thomas, Tomas de Wouters, Gilbert Greub, Thomas Clavel, Eric G Pamer, Adrian Egli, Lisa Maier, Pascale Vonaesch (2023)

14: 1104707

The cyanobacterial “nutraceutical” phycocyanobilin inhibits cysteine protease legumain.

Isabel VL Wilkinson, Gabriel Castro‐Falcón, Maria C Roda‐Serrat, Trevor N Purdy, Jan Straetener, Melanie M Brauny, Lisa Maier, Heike Brötz‐Oesterhelt, Lars P Christensen, Stephan A Sieber, Chambers C Hughes (2023)

ChemBioChem, 5, e202200455

2022

Codiversification of gut microbiota with humans.

Suzuki, T. A., Fitzstevens, L., Schmidt, V.T., Enav‚ H., Huus, K. E., Mbong Ngwese, M., Grießhammer, A., Pfleiderer, A., Adegbite, B., R., Zinsou, J. F., Esen, M., Velavan, T., P., Adegnika, A. A., Huu Song, L., Spector, T. D., Muehlbauer, A. L., Marchi, N., Kang, H., Maier, L., Blekhman, R., Ségurel, L., Ko, G., Youngblut, N. D., Kremser, P., Ley, R. E. (2022).

Science, 377, pages 1328-1332

2021

Unravelling the collateral damage of antibiotics on gut bacteria.

Maier, L.#*, Goemans, C. V.*, Wirbel, J., Kuhn, M., Eberl, C., Pruteanu, M., Müller, P., Garcia-Santamarina, S., Cacace, E., Zhang, B., Gekeler, C., Banerjee, T., Anderson, E. E., Milanese, A., Löber, U., Forslund, S. K., Patil, K. R., Zimmermann, M., Stecher, B., … Typas, A.# (2021).

Nature, 599, pages 120-124

Bioaccumulation of therapeutic drugs by human gut bacteria.

Klünemann, M., Andrejev, S., Blasche, S., Mateus, A., Phapale, P., Devendran, S., Vappiani, J., Simon, B., Scott, T. A., Kafkia, E., Konstantinidis, D., Zirngibl, K., Mastrorilli, E., Banzhaf, M., Mackmull, M.-T., Hövelmann, F., Nesme, L., Brochado, A. R., Maier, L., … Patil, K. R. (2021).

Nature, 597, 533-538

Towards a mechanistic understanding of reciprocal drug-microbiome interactions.

Zimmermann, M.#, Patil, K. R., Typas, A., & Maier, L.# (2021).

Molecular Systems Biology, 17(3), e10116.

2019

Escherichia coli limits Salmonella Typhimurium infections after diet shifts and fat-mediated microbiota perturbation in mice .

Wotzka, S. Y., Kreuzer, M., Maier, L., Arnoldini, M., Nguyen, B. D., Brachmann, A. O., Berthold, D. L., Zünd, M., Hausmann, A., Bakkeren, E., Hoces, D., Gül, E., Beutler, M., Dolowschiak, T., Zimmermann, M., Fuhrer, T., Moor, K., Sauer, U., Typas, A., … Hardt, W.-D. (2019).

Nature Microbiology, 4(12), 2164–2174.

Komplexe Wechselwirkungen zwischen Arzneimitteln und dem Mikrobiom.

Maier, L. (2019).

BIOspektrum, 25(7), 707–710.

2018

Microbiota stability in healthy individuals after single-dose lactulose challenge—A randomized controlled study.

Wotzka, S. Y.*, Kreuzer, M.*, Maier, L.*, Zünd, M., Schlumberger, M., Nguyen, B., Fox, M., Pohl, D., Heinrich, H., Rogler, G., Biedermann, L., Scharl, M., Sunagawa, S., Hardt, W.-D., & Misselwitz, B. (2018).

PLOS ONE, 13(10), e0206214.

Extensive impact of non-antibiotic drugs on human gut bacteria.

Maier, L.*, Pruteanu, M.*, Kuhn, M.*, Zeller, G., Telzerow, A., Anderson, E. E., Brochado, A. R., Fernandez, K. C., Dose, H., Mori, H., Patil, K. R., Bork, P., & Typas, A. (2018).

Nature, 555(7698), 623–628.

2017

Systematically investigating the impact of medication on the gut microbiome.

Maier, L., & Typas, A. (2017).

Current Opinion in Microbiology, 39, 128–135.

Salt-responsive gut commensal modulates TH17 axis and disease.

Wilck, N., Matus, M. G., Kearney, S. M., Olesen, S. W., Forslund, K., Bartolomaeus, H., Haase, S., Mähler, A., Balogh, A., Markó, L., Vvedenskaya, O., Kleiner, F. H., Tsvetkov, D., Klug, L., Costea, P. I., Sunagawa, S., Maier, L., Rakova, N., Schatz, V., … Müller, D. N. (2017).

Nature, 551(7682), 585–589.

2015

Granulocytes Impose a Tight Bottleneck upon the Gut Luminal Pathogen Population during Salmonella Typhimurium Colitis.

Maier, L., Diard, M., Sellin, M. E., Chouffane, E.-S., Trautwein-Weidner, K., Periaswamy, B., Slack, E., Dolowschiak, T., Stecher, B., Loverdo, C., Regoes, R. R., & Hardt, W.-D. (2014).

PLoS Pathogens, 10(12), e1004557.

Salmonella Typhimurium Strain ATCC14028 Requires H2-Hydrogenases for Growth in the Gut, but Not at Systemic Sites.

Maier, L., Barthel, M., Stecher, B., Maier, R. J., Gunn, J. S., & Hardt, W.-D. (2014).

PLoS ONE, 9(10), e110187.

2013

“Blooming” in the gut: How dysbiosis might contribute to pathogen evolution.

Stecher, B., Maier, L., & Hardt, W.-D. (2013).

Nature Reviews. Microbiology, 11(4), 277–284.

Microbiota-Derived Hydrogen Fuels Salmonella Typhimurium Invasion of the Gut Ecosystem.

Maier, L., Vyas, R., Cordova, C. D., Lindsay, H., Schmidt, T. S. B., Brugiroux, S., Periaswamy, B., Bauer, R., Sturm, A., Schreiber, F., von Mering, C., Robinson, M. D., Stecher, B., & Hardt, W.-D. (2013).

Cell Host & Microbe, 14(6), 641–651.

Stabilization of cooperative virulence by the expression of an avirulent phenotype.

Diard, M., Garcia, V., Maier, L., Remus-Emsermann, M. N. P., Regoes, R. R., Ackermann, M., & Hardt, W.-D. (2013).

Nature, 494(7437), 353–356.

2012

Live attentuated S. Typhimurium vaccine with improved safety in immuno-compromised mice.

Periaswamy, B., Maier, L., Vishwakarma, V., Slack, E., Kremer, M., Andrews-Polymenis, H. L., McClelland, M., Grant, A. J., Suar, M., & Hardt, W.-D. (2012).

PloS One, 7(9), e45433.

Peroral ciprofloxacin therapy impairs the generation of a protective immune response in a mouse model for Salmonella enterica serovar Typhimurium diarrhea, while parenteral ceftriaxone therapy does not.

Endt, K.*, Maier, L.*, Käppeli, R., Barthel, M., Misselwitz, B., Kremer, M., & Hardt, W.-D. (2012).

Antimicrobial Agents and Chemotherapy, 56(5), 2295–2304.

Gut inflammation can boost horizontal gene transfer between pathogenic and commensal Enterobacteriaceae.

Stecher, B., Denzler, R., Maier, L., Bernet, F., Sanders, M. J., Pickard, D. J., Barthel, M., Westendorf, A. M., Krogfelt, K. A., Walker, A. W., Ackermann, M., Dobrindt, U., Thomson, N. R., & Hardt, W.-D. (2012).

PNAS, 109(4), 1269–1274.

2010

Glycosylation of wall teichoic acid in Staphylococcus aureus by TarM.

Xia, G., Maier, L., Sanchez-Carballo, P., Li, M., Otto, M., Holst, O., & Peschel, A. (2010).

The Journal of Biological Chemistry, 285(18), 13405–13415.

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* equal contribution, # corresponding authors